姓名：阿斯根

职称：特聘研究员、博士生导师

地址：华东理工大学徐汇校区实验十二楼504室

邮箱：sigen.a@ecust.edu.cn

个人经历

主要研究方向——功能高分子生物医用材料开发及其应用

·     可控活性聚合技术合成的新型超支化PEG聚合物及其功能化应用

·     天然高分子聚合物（透明质酸、硫酸软骨素、壳聚糖、明胶、胶原、角蛋白等）的改性及功能化

·     功能性可注射水凝胶在组织工程学、软组织伤口愈合、软骨/骨修复、干细胞载体、药物载体及 3D 打印方向的应用

研究项目情况

·     爱尔兰科学基金会（SFI）企业联合资助项目，一种可用于胸骨粘合的新一代紫外交联超支化聚β氨基酯组织交联剂的构建，2020，52277.75 欧元，项目主持。

·     爱尔兰科学基金会（SFI）未来创新者项目，一种颠覆性的、非病毒基因编辑平台技术用于遗传疾病的治疗，2019，217070 欧元，核心参与人员。

·     爱尔兰科学基金会（SFI）项目，原位皮肤替代物结合基因疗法修复皮肤创伤，2014，1180000 欧元，核心参与人员。

产业转化项目情况

1.  新型透明质酸凝胶型皮肤填充剂开发，项目主持；

2.  新型胶原蛋白皮肤填充剂的开发（无交联剂体系），项目主持；

3.  原位交联透明质酸水凝胶结合脐血干细胞治疗慢性伤口愈合，材料项目主持（北科生物合作项目）；

4.  原位交联透明质酸水凝胶结合间充质干细胞治疗软骨愈合，材料项目主持（深圳大学合作项目）；

5.  原位交联透明质酸水凝胶结合倍他米松治疗腰椎间盘突出引发的疼痛，材料项目主持（浙江大学一附院骨科合作项目）；

6.  原位交联透明质酸水凝胶膀胱黏膜保护剂的开发，材料项目主持（北京医学泌尿科合作项目）

荣誉奖励

1.  安徽省海外引才计划青年百人学者（2023年）；

2.  中国留学基金委优秀留学生奖学金（非公派）2019年获奖者（全球五百名）。

学术成果

累积发表第一/通讯作者（含共同）论文21篇，包括J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Mater.、Adv. Func. Mater.等。申请国际PCT发明专利5件，授权中国发明专利3件。

1.   Milne, C., Song, R.,* Johnson, M., Zhao, C., Santoro, F., A, S.,* Lyu, J., Wang, W.*, ‘Dual-Modified Hyaluronic Acid for Tunable Double Crosslinked Hydrogel Adhesives’. Biomacromolecules, 2024, 25, 2645-2655, DOI: 10.1021/acs.biomac.4c00194.

2.   Song, R., Wang, X., Johnson, M., Milne, C., Lesniak-Podsiadlo, A., Li, Y., Lyu, J., Li, Z., Zhao, C., Yang, L., Lara-Sáez, I., A, S.,* Wang, W.*,‘Enhanced Strength for Double Network Hydrogel Adhesive Through Cohesion-Adhesion Balance’. Advanced Functional Materials, 2024, 202313322, DOI:10.1002/adfm.202313322.

3.  Ma, B., Shi, J., Zhang, Y., Li, Z., Yong, H., Zhou, Y.,* Liu, S.,* A, S.,* Zhou, D.*, Enzymatically Activatable Polymers for Disease Diagnosis and Treatment. Advanced Materials, 2023, 2306358, DOI: 10.1002/adma.202306358.

4.  Shi, J., Ma, B., Zhang, Y., Yong, H., Li, Z., A, S.,* Huang, H.,* Zhou, D.*, Targeted Delivery of Anticancer Therapeutics with Polymers by Harnessing Tumor Microenvironment Acidity. Chemistry of Materials, 2023, 35, 6573, DOI: 10.1021/acs.chemmater.3c01151.

5.   Li, Y., Wang, X., He, Z., Johnson, M., A, S.,* Lara-Sáez, I., Lyu, J.,* Wang, W.*, 3D Macrocyclic Structure Boosted Gene Delivery: Multi-cyclic Poly(β-Amino Ester)s from Step Growth Polymerization. Journal of the American Chemical Society, 2023, 145, 17187, DOI: 10.1021/jacs.3c04191.

6.   Wang, X., Johnson, M., Zhang, N., Shen, P., Yang, L., Milne, C., Lara-Saez, I., Song, R.,* A, S.,* Wang, W., Stimuli-responsive chitosan-based injectable hydrogel for ‘‘on-demand’’ drug release. Materials Advances, 2023, 4, 6439, DOI: 10.1039/d3ma00430a.

7.   Li, X., Xu, Q., Johnson, M., Wang X., Lyu, J., Li, Y., McMahon S., Greiser U., A, S.*, Wang, W.*, A Chondroitin Sulfate based Injectable Hydrogel for Delivery of Stem Cells in Cartilage Regeneration. BIOMATERIALS SCIENCE, 2021, 9, 4139, DOI: 10.1039/d1bm00482d.

8.  A, S., Xu, Q.*, Johnson, M., Creagh-Flynn, J., Venet, M., Zhou, D., Lara-Saez, I., Tai, H., Wang, W.*, An Injectable Multi-Responsive Hydrogel as Self-Healable and On-demand Dissolution Tissue Adhesive. APPLIED MATERIALS TODAY, 2021, 22, 100967, DOI: 10.1016/j.apmt.2021.100967.

9.   A, S., Lyu, J., Johnson, M., Creagh-Flynn, J., Zhou, D., Lara-Sez, I., Xu, Q.,* Tai, H., Wang, W.* , An Instant Gelation System as Self-Healable and Printable 3D Cell Culture Bio-Ink based on Dynamic Covalent Chemistry. ACS Applied Materials & Interfaces, 2020, 12, 35, 38918-38924, DOI: 10.1021/acsami.0c08567.

10. A, S., Zeng, M., Johnson, M., Creagh-Flynn, J., Xu, Q.,*, Tai, H., Wang, W.*, Green Synthetic Approach for Photo-Cross-Linkable Methacryloyl Hyaluronic Acid with a Tailored Substitution Degree. Biomacromolecules, 2020, 21, 2229-2235, DOI: 10.1021/acs.biomac.0c00196.

11. Yong, H., Miao, Y., A, S.,* Quan, D., Ivankovic, A., Singh, K., Zhang, J., Zhou, D., Wang, W.* , Branched Polystyrenes from a Suspension “Strathclyde” Polymerization Using a Vulcanization Accelerator as Chain Transfer Agent’. Polymer Chemistry, 2019, 10, 885-890, DOI: 10.1039/C8PY01639A.

12.  Xu, Q., A, S., Venet, M., Gao, Y., Zhou, D.*, Wang, W., Zeng, M., Rotella, C., Li, X., Wang, X., Lyu, J., Rodriguez, B. J., Wang, W.* ‘Bacterial-Resistant Single Chain Cyclized/Knotted Polymer Coatings. Angewandte Chemie International Edition, 2019, 131 (31), 10726-10730, DOI: 10.1002/anie.201904818. (co-first author)

13.  Xu, Q., Venet, M., Wang, W., Creagh-Flynn, J., Wang, X., Li, X., Gao, Y., Zhou, D., Zeng, M, Lara-Sáez, I., A, S.,* Tai, H., Wang, W.* , Versatile Hyperbranched Poly(β-hydrazide ester) Macromers as Injectable Antioxidative Hydrogels.ACS Applied Materials & Interfaces, 2018, 10 (46), pp 39494–39504. DOI: 10.1021/acsami.8b15006.

14.  Xu, Q.; A, S.,; Gao, Y.; Guo, L.; Creagh-Flynn, J.; Zhou, D.; Greiser, U.; Dong, Y.; Wang, F.; Tai, H.; Liu, W.; Wang, W.*; Wang, W.* , A Hybrid Injectable Hydrogel from Hyperbranched PEG Macromer as a Stem Cell Delivery and Retention Platform for Diabetic Wound Healing. Acta Biomaterialia, 2018, 75, 63–74. DOI: 10.1016/j.actbio.2018.05.039. (IF=6.383) (co-first author)

15.  Xu, Q.; A, S.*; McMichael, P.; Creagh-Flynn, J.; Zhou, D.; Gao, Y.; Li, X.; Wang, X.; Wang, W.*, Double-Cross-Linked Hydrogel Strengthened by UV Irradiation from a Hyperbranched PEG-Based Trifunctional Polymer.ACS Macro Letters, 2018, 7 (5), 509–513. DOI: 10.1021/acsmacrolett.8b00138. (IF=6.131)

16. A, S.; Xu, Q.; McMichael, P.; Gao, Y.; Li, X.; Wang, X.; Greiser, U.; Zhou, D.; Wang, W.* , A Facile One-Pot Synthesis of Acrylated Hyaluronic Acid. Chemical Communications, 2018, 54 (9), 1081–1084. DOI: 10.1039/C7CC08648B. (IF=6.29)

17.  A, S.; Xu, Q.; Zhou, D.; Gao, Y.; Vasquez, J. M.; Greiser, U.; Wang, W.; Liu, W.; Wang, W.*, Hyperbranched PEG-Based Multi-NHS Polymer and Bioconjugation with BSA’. Polymer Chemistry, 2017, 8 (8), 1283–1287.DOI: 10.1039/C6PY01719C. (IF=4.927)

18. O'Keeffe Ahern, J., A, S., Zhou, D., Gao, Y., Lyu, J., Meng, Z., Cutlar, L., Pierucci, L., Wang, W.* , Brush-like Cationic Polymers with Low Charge Density for Gene Delivery. BIOMACROMOLECULES, 2018, 19, 1410-1415, DOI: 10.1021/acs.biomac.7b01267. (IF=5.65) (co-first author)

19. A, S., Y. Zhang, Z. Li, H. Xia, M. Xue, X. Liu, Y. Mu, Highly efficient and reversible iodine capture using a metalloporphyrin-based conjugated microporous polymer. Chemical Communications, 2014, 50, 8495–8498. DOI: 10.1039/C4CC01783H. (IF=6.29)

20. X. Liu, A, S., Y. Zhang, X. Luo, H. Xia, H. Li, Y. Mu, A porphyrin-linked conjugated microporous polymer with selective carbon dioxide adsorption and heterogeneous organocatalytic performances. RSC Advances, 2014, 4(13), 6447-6453. DOI: 10.1039/C3RA46988C. (IF=3.16)

21. A, S., X. Liu, H. Li, C. He, Y. Mu, Direct CH Arylation of Unactivated Arenes with Aryl Halides Promoted by Bis (imino) pyridine Derivatives. ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2(10), 857-861. DOI: 10.1002/ajoc.201300129 (IF=2.53)